The zygomaticus major (also zygomaticus major muscle, major zygomatic muscle, latin: musculus zygomaticus major) is a paired muscle of facial expression, stretching between the zygomatic bone and the corner of the mouth. It is one of the two zygomatic muscles (major and minor).
The zygomaticus major originates from the zygomatic arch and inserts into the skin of the angle of the mouth.
The zygomaticus major muscle lifts the angle of the mouth upwards and laterally. Contractions of this muscle produce facial expression of pleasure or laughter.
The innervation of the zygomaticus major is received from the buccal branch of the facial nerve (CN VII).